Physico-mechanical properties of soft clay in Zhuhai Region have been achieved according to the data collected from the in-situ tests. Results show that the characteristics of soft soil in Zhuhai Region are with higher water content,higher compressive property,and lower load capacity. The soils have the strongly structural characteristics and preconsolidation characteristics too. Based on a detailed investigation into the previous engineering construction in Zhuhai Region and the experience with both successful and failure results,an overview is withdrawn on the soft soil treatment,soft soil foundation pit,pile foundation and other geotechnical engineering issues.