Abstract：The Shizhuyuan polymetallic mine is mining by room-and-pillar open stope method for more than 10 years. After 36 designed rooms are mined out，there left 260×104 cubic meters mined-out areas with 8 000 square meters of the maximum continuous exposed face of roof without filling for some reasons. For the sustainable mine development and the safe mining，one main issue is how to management of multi-mined-out-area and the pillar mining. After comparison of many calculation methods，the caving method is chosen. Some useful results are achieved as follows. (1) After the proper evaluation of engineering geology with RMR，Q，MRMR and GSI systems，the mechanical parameters of rock mass are derived by generalized Hoek-Brown failure criterion. (2) After the stability of residual pillar is calculated by Bieniawski method，many mining schemes for the determination of mining method are modeled by three-dimensional elastoplastic finite element method. Based on the modeling and analytical results，the caving method is finally selected. (3) Caving areas for each stage of caving mining is figured out by the latest Laubscher caving stability graph method and extended Mathews stability method. (4) Strata displacement parameters such as caving angle are determined by the radial basis function neural network；the height of cushioning layers for different mined-out-areas is established. (5) For the purpose of safety mining，the ground pressure monitoring system such as acoustic emission，displacement and pressure that are suitable for the hard rock mining are designed and installed. The technological routes of the ground monitoring and an early warning case are also listed，which are proven to be successful with practical data.
