Abstract：The seepage of groundwater is a progress of water-rock interaction，so the study of water-rock interaction is very important for environmental problems and engineering application. 3D coupling model in low permeability groundwater environment is established based on the liquid-solid mechanics，and the variable separation method is adopted to get the solution of one-dimension model. The variation laws of pressure and permeability coefficient with distance and time are obtained with a practical example shown. The values predicted by the model are in good agreement with the measured values which demonstrates the applicability and validity of the model.
